CD4 T cells and toxicity from immune checkpoint blockade

Immunological Reviews

Earland N, Zhang W, Usmani A, Nene A, Bacchiocchi A, Chen DY, Sznol M, Halaban R, Chaudhuri AA, Newman AM. PMID: 37491734

Melanoma in a patient with DNMT3A overgrowth syndrome

Cold Spring Harbor Molecular Case Studies

Chen DY#, Sutton LA, Ramakrishnan SM, Duncavage EJ, Heath SE, Compton LA, Miller CA, Ley TJ. PMID: 37160317.


Combined Kdm6a and Trp53 deficiency drives the development of squamous cell skin cancer in mice

Journal of Investigative Dermatology

Shea LK*, Akhave NS*, Sutton LA, Compton LA, York C, Ramakrishnan SM, Miller CA, Wartman LD, Chen DY#. PMID: 36055401.

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells


Smith AM, Verdoni AM, Abel HJ, Chen DY, Ketkar S, Leight ER, Miller CA, Ley TJ. PMID: 35313694.

T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma

Nature Medicine

Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. PMID: 35027754.


Functional and epigenetic phenotypes of humans and mice with DNMT3A overgrowth syndrome

Nature Communications

Smith AM, LaValle TA, Shinawi M, Ramakrishnan SM, Abel HJ, Hill CA, Kirkland NM, Retting MP, Helton NM, Heath SE, Ferraro F, Chen DY, Adak S, Semenkovich CF, Christian DL, Martin JR, Gabel HW, Miller CA, Ley TJ. (2021) PMID: 34315901.

Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype

Proceedings of the National Academy of Sciences

Chen DY, Ferguson IM, Braun KA, Sutton LA, Ramakrishnan SM, Helton NM, Smith AM, Miller CA, Ley TJ. (2021) PMID: 33846253.

Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

Proceedings of the National Academy of Sciences

Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight E, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Petti AA, Spencer DH, Miller CA, Ley TJ. (2020) PMID: 31996479.

A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing

Nature Communications

Petti A, Williams SR, Miller CA, Fiddes IT, Srivatsan SN, Chen DY, Fronick CC, Fulton RS, Church DM, Ley TJ. (2019) PMID: 31413257.

DNMT3AR882-associated hypomethylation is maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line

Blood Cancer Journal

Chen DY, Christopher M, Helton N, Ferguson I, Ley TJ, Spencer DH. (2018) PMID: 29618788

*Equal contribution
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