2023
CD4 T cells and toxicity from immune checkpoint blockade
Immunological Reviews
Earland N, Zhang W, Usmani A, Nene A, Bacchiocchi A, Chen DY, Sznol M, Halaban R, Chaudhuri AA, Newman AM. PMID: 37491734
Melanoma in a patient with DNMT3A overgrowth syndrome
Cold Spring Harbor Molecular Case Studies
Chen DY#, Sutton LA, Ramakrishnan SM, Duncavage EJ, Heath SE, Compton LA, Miller CA, Ley TJ. PMID: 37160317.
2022
Combined Kdm6a and Trp53 deficiency drives the development of squamous cell skin cancer in mice
Journal of Investigative Dermatology
Shea LK*, Akhave NS*, Sutton LA, Compton LA, York C, Ramakrishnan SM, Miller CA, Wartman LD, Chen DY#. PMID: 36055401.
Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells
iScience
Smith AM, Verdoni AM, Abel HJ, Chen DY, Ketkar S, Leight ER, Miller CA, Ley TJ. PMID: 35313694.
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma
Nature Medicine
Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. PMID: 35027754.
2018-2021
Functional and epigenetic phenotypes of humans and mice with DNMT3A overgrowth syndrome
Nature Communications
Smith AM, LaValle TA, Shinawi M, Ramakrishnan SM, Abel HJ, Hill CA, Kirkland NM, Retting MP, Helton NM, Heath SE, Ferraro F, Chen DY, Adak S, Semenkovich CF, Christian DL, Martin JR, Gabel HW, Miller CA, Ley TJ. (2021) PMID: 34315901.
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype
Proceedings of the National Academy of Sciences
Chen DY, Ferguson IM, Braun KA, Sutton LA, Ramakrishnan SM, Helton NM, Smith AM, Miller CA, Ley TJ. (2021) PMID: 33846253.
Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing
Proceedings of the National Academy of Sciences
Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight E, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Petti AA, Spencer DH, Miller CA, Ley TJ. (2020) PMID: 31996479.
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing
Nature Communications
Petti A, Williams SR, Miller CA, Fiddes IT, Srivatsan SN, Chen DY, Fronick CC, Fulton RS, Church DM, Ley TJ. (2019) PMID: 31413257.
DNMT3AR882-associated hypomethylation is maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line
Blood Cancer Journal
Chen DY, Christopher M, Helton N, Ferguson I, Ley TJ, Spencer DH. (2018) PMID: 29618788