We aim to utilize multi-omic and high-throughput approaches to uncover (i) how circRNA translation is differentially regulated under normal, stress, and disease conditions, (ii) how circRNAs regulate cellular functions at single-cell and whole tissue levels, and (iii) how to utilize circRNA translation as a novel platform for cancer treatment. Our long-term goal is to harness the unique biochemical and molecular features of circRNAs to develop new tools for RNA-based technologies and therapeutic interventions.
Select Publications
Engineering circular RNA for enhanced protein production
Nature Biotechnology
July 2022
Chen R., Wang S.K., Belk J.A., Amaya L., Li Z., Cardenas A., Abe B.T., Chen C.-K., Wender P.A., and Chang H.Y.
Structured elemens drive extensive circular RNA translation
Molecular Cell
October 2021
Chen C.-K., Cheng R., Demeter J., Chen J., Weingarten-Gabbay S., Jiang L., Snyder M.P., Weissman J.S., Segal E., Jackson P.K., and Chang H.Y.
Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
Science
August 2016
Chen C.-K., Blanco M., Jackson C., Aznauryan E., Ollikainen N., Surka C., Chow A., Cerase A., McDonel P., and Guttman M.
m(6)A RNA methylation promotes XIST-mediated transcriptional repression
Nature
September 2016
Patil D.P., Chen C.-K., Pickering B.F., Chow A., Jackson C., Guttman M., and Jaffrey S.R.
The Xist IncRNA interacts directly with SHARP to silence transcription through HDAC3
Nature
April 2015
McHugh C.A.*, Chen C.-K.*, Chow A., Surka C.F., Tran C., McDonel O., Pandya-Jones A., Blanco M., Burghard C., Moradian A., Sweredoski M.J., Shishkin A.A., Su J., Lander E.S., Hess S., Plath K., and Guttman M. *Co-first authors
Join Us!
The Chen Lab is always looking for new team members. Learn more about our lab and how to join!