Chemical stability of petrichorins. Li, C., Sarotti, A., Wu, X., Zheng, S-L., Blodgett, JAV., Cao, S. The Journal of Organic Chemistry. 2022. DOI: 10.1021/acs.joc.2c01275
Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster; C Li, Y Hu, X Wu, SD Stumpf, Y Qi, JM D’Alessandro, KK Nepal, AM Sarotti, S Cao, JAV Blodgett. PNAS, 2022. DOI: 10.1073/pnas.2117941119
Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C–H Bond Activations. J Yang, Y Qi, JAV Blodgett, TA Wencewicz. Journal of Natural Products, 2022. DOI: 10.1021/acs.jnatprod.1c00606
A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity, Y Qi, KK Nepal, JAV Blodgett. PNAS, 2021. DOI: 10.1073/pnas.2103515118
Draft Genome Sequences of Two Polycyclic Tetramate Macrolactam Producers, Streptomyces sp. Strains JV180 and SP18CM02. Qi Y, Nepal KK, Greif J, Martini C, Tomlinson C, Markovic C, Fronick C, Blodgett JAV. Microbiol Resour Announc. 2020 Dec 10;9(50):e01066-20. PMID: 33303657. DOI: 10.1128/MRA.01066-20.
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Uddhav K. Shigdel, Seung-Joo Lee, Mathew E. Sowa, Brian R. Bowman, Keith Robison, Minyun Zhou, Khian Hong Pua, Dylan T. Stiles, Joshua A. V. Blodgett, Daniel W. Udwary, Andrew T. Rajczewski, Alan S. Mann, Siavash Mostafavi, Tara Hardy, Sukrat Arya, Zhigang Weng, Michelle Stewart, Kyle Kenyon, Jay P. Morgenstern, Ende Pan, Daniel C. Gray, Roy M. Pollock, Andrew M. Fry, Richard D. Klausner, Sharon A. Townson, and Gregory L. Verdine. PNAS, 2020. DOI: 10.1073/pnas.2006560117
Construction of a new integrating vector from actinophage ΦOZJ and its use in multiplex Streptomyces transformation. B Ko, JM D’Alessandro, L Douangkeomany, SD Stumpf, A deButts, JAVBlodgett. Journal of Industrial Microbiology & Biotechnology, 2019. PMID: 31705217; DOI: 10.1007/s10295-019-02246-7
Bioinformatic and Functional Evaluation of Actinobacterial Piperazate Metabolism. Y Hu, Y Qi, SD Stumpf, JM D’Alessandro, JAV Blodgett. ACS Chemical Biology, 2019. DOI: 10.1021/acschembio.8b01086
Native and Engineered Clifednamide Biosynthesis in Multiple Streptomyces spp. ACS Synthetic Biology, 2018. YI Qi, E Ding, JAV Blodgett. DOI: 10.1021/acssynbio.7b00349
Draft Genome Sequence of Streptomyces sp. Strain JV178, a Producer of Clifednamide-Type Polycyclic Tetramate Macrolactams. Y Qi, JM D’Alessandro, JAV Blodgett. Genome Announcements, 2018.DOI: 10.1128/genomeA.01401-17
Chemical and Biological Aspects of Nutritional Immunity – Perspectives for New Anti-infectives Targeting Iron Uptake Systems. Ursula Bilitewski, Joshua AV Blodgett, Anne‐Kathrin Duhme‐Klair, Sabrina Dallavalle, Sabine Laschat, Anne Routledge, Rainer Schobert. Angewandte Chemie (International ed. in English), 2017. PMID: 28439959; DOI: 10.1002/anie.201701586
Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products. JAV Blodgett, JK Zhang, X Yu, WW Metcalf. The Journal of Antibiotics, 2016. PMID: 26328935; DOI: 10.1038/ja.2015.77
Cellulolytic Streptomyces strains associated with herbivorous insects share a phylogenetically linked capacity to degrade lignocellulose. Adam J Book, Gina R Lewin, Bradon R McDonald, Taichi E Takasuka, Drew T Doering, Aaron S Adams, Joshua AV Blodgett, Jon Clardy, Kenneth F Raffa, Brian G Fox, Cameron R Currie. ASM Applied and Environmental Microbiology, 2014. PMID: 24837391; PMC: PMC4148805; DOI: 10.1128/AEM.01133-14
Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain. Shugeng Cao, Joshua AV Blodgett, Jon Clardy. Organic Letters, 2010. PMID: 20843016; PMC: PMC2952660; DOI: 10.1021/ol1020064
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. JAV Blodgett, DC Oh, S Cao, CR Currie, R Kolter, J Clardy. PNAS, 2010. PMID: 20547882; PMC: PMC2900643; DOI: 10.1073/pnas.1001513107
Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Mohammad R Seyedsayamdost, Josephine R Chandler, Joshua AV Blodgett, Patricia S Lima, Breck A Duerkop, Ken-Ichi Oinuma, E Peter Greenberg, Jon Clardy. Organic Letters, 2010. PMID: 20095633; PMC: PMC2821070; DOI: 10.1021/ol902751x
An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Robert M Cicchillo, Houjin Zhang, Joshua AV Blodgett, John T Whitteck, Gongyong Li, Satish K Nair, Wilfred A van der Donk, William W Metcalf. Nature, 2009. PMID: 19516340; PMC: PMC2874955; DOI: 10.1038/nature07972
Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. Journal of Biological Chemistry, 2008. PMID: 18544530; PMC: PMC2516978; DOI: 10.1074/jbc.M801788200
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Joshua AV Blodgett, Paul M Thomas, Gongyong Li, Juan E Velasquez, Wilfred A Van Der Donk, Neil L Kelleher, William W Metcalf. Nature Chemical Biology, 2007. PMID: 17632514; PMC: PMC4313788; DOI: 10.1038/nchembio.2007.9
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Ryan D Woodyer, Zengyi Shao, Paul M Thomas, Neil L Kelleher, Joshua AV Blodgett, William W Metcalf, Wilfred A van der Donk, Huimin Zhao. Chemistry and Biology, 2006. PMID: 17113999; DOI: 10.1016/j.chembiol.2006.09.007
Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736. JAV Blodgett, JK Zhang, WW Metcalf. ASM Antimicrobial Agents and Chemotherapy, 2005. PMID: 15616300; PMC: PMC538901; DOI: 10.1128/AAC.49.1.230-240.2005