Cannabidiol and the DEA

The US FDA approved Epidiolex® (cannabidiol, or CBD) for certain seizure syndromes in June, and today the DEA listed it as a Schedule V controlled substance (the least restrictive). This action will greatly facilitate clinical use and clinical trials of CBD in the U.S. Note that there is little evidence at this point that CBD […]

Testing a new strategy to treat Tourette syndrome in children

We were happy to participate in the first-ever study of a dopamine D1 blocking drug in children with TS. The study results were recently published, showing evidence of benefit without substantial side effects. Click here for additional background information, a summary of the results, and a link to the publication. (

Tic suppression research

This web page describes a recent publication from Wash.U. and several other research sites on factors associated with successful tic suppression in 99 children and adolescents with a tic disorder.

Management of tardive dyskinesia 2018

A colleague asked me about treatment for tardive dyskinesia and I thought I’d share my answer. Here is a rough outline as I see it, in approximate order. Make sure it is tardive dyskinesia. You’re looking for involuntary, rhythmic stereotypies at about 0.5-1.0 Hz. They may be suppressible with effort but sometimes are not noticed […]

A measured response to CNN’s article on Nuplazid®

A recent article from CNN discussed Nuplazid® (pimavanserin), a medication approved by the FDA in 2016 for treatment of hallucinations or delusions in Parkinson’s disease (a.k.a. PDP, for Parkinson disease psychosis). The article made some efforts to present a balanced perspective, but the title and overall tenor of the article focused on the possibility that this new […]

Gentle steps to open publishing

Next time you think you have to give your copyright away to a big-name journal, there are alternatives. Read more here. Sample quote: … Personally, in an age in which the ‘Paper User Interface’ is almost obsolete, and I almost always find papers from PubMed or Google, giving my rights away to a journal (by copyright […]

Marijuana for tics?

Here’s a brief summary of what we know about cannabis and related drugs for treatment of tics.