Professor of Pathology & Immunology
Professor of Biochemistry & Molecular Biology
Professor of Molecular Microbiology
Department of Pathology and Immunology
Washington University School of Medicine in St. Louis
BS, Biochemistry: City College of New York/CUNY, New York, New York (1997)
PhD, Biochemistry: University of Maryland, Baltimore, MD (2001)
The overarching goal of my research program is to develop a mechanistic understanding of host-pathogen interactions with biological consequences to pathogenesis. These interactions promote host immune suppression and enhance pathogen replication in cell and tissue specific manner, but remain incompletely described. Results from these studies will inform on molecular mechanisms of action during infection as well as insights into potential therapeutic targets and mechanisms of action. We currently use biochemical and biophysical methods to identify and characterize components from hosts and pathogens in order to develop an atomic resolution framework. Importantly, these efforts also provide opportunities to mentor a range of trainees, including undergraduates, graduate students and postdoctoral fellows.
Figures from Ivanov A, Ramanathan P, Parry C, Ilinykh PA, Lin X, Petukhov M, Obukhov Y, Ammosova T, Amarasinghe GK, Bukreyev A, Nekhai S. Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription. Cell Mol Life Sci. 2020 Jul;77(13):2579-2603. doi: 10.1007/s00018-019-03303-1. Epub 2019 Sep 28. PMID: 31562565; PMCID: PMC7101265.
Meet the Lab
Address: 4939 Childrens Place St. Louis, MO 63110